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Mediators Inflammation (2022) 2022:2944156

Parameter estimation

This interaction may provide the potential foundation for the development and persistence of PEM symptoms, establishing a potential molecular and metabolic framework for the pathophysiology of PEM

[9,18] Although pharmacologic approaches are the most important treatment strategies for MDD, response rates to the first-line antidepressants are moderate and remission is observed in about 3045% of patients

The precise mechanism behind this divergence, whether related to receptor distribution, blood-brain barrier penetration, or differential hypothalamic engagement, is not fully defined in the published literature