Cytotoxicity, cellular uptake, and mitochondrial targeting capability of CMH@lip@Res-TCeO 2 The cytotoxicity, cellular uptake, and mitochondrial targeting ability of CMH@lip@Res-TCeO 2 were evaluated in vitro (schematic illustration shown in Fig
These results were validated using fluorescent miscroscopy and immunocytochemical staining ( Figure 4B ), which showed that CB-839 induced the accumulation of LC3 puncta in HG-3 and MEC-1 cells
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The Fmoc group was then removed according to the method above, and the final amino acid was attached using the same method as the second amino acid
It has also been proven crucial in the bodys drug resistance, in particular resistance against anticancer drugs