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Doll's team found that ACSL4 deficiency enhances cellular resistance to GPX4-deficient ferroptosis, whereas LPCAT3 knockout fails to afford robust protection, implying a potential alternative system between these enzymes [88]
It has a strong antioxidant effect by neutralizing free radicals and reactive oxygen compounds, as well as maintaining exogenous antioxidants such as Vitamin C and E
Oxidative stress has been clarified to be related to the occurrence and progression of numerous diseases, including musculoskeletal diseases, cardiovascular diseases, respiratory diseases, dermatological diseases, neurodegenerative diseases, gastrointestinal diseases, cancer, and the aging process [7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]
Replenishing it supports DNA repair, mitochondrial function, and cellular integrity from the inside out
3.3 Mitochondria and the plasma membrane At the cell periphery, these intracellular mechanisms converge on the plasma membrane, where calcium entry both drives physiological secretion and, when excessive, perpetuates mitochondrial injury
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