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Similarly, ASD risk was higher for those in the middle third (2.14 times) and highest third (3.62 times)

The downstream effects most consistently described in the literature: induction of collagen I and III, elastin, and decorin synthesis (Maquart et al., FEBS Letters , 1988), upregulation of VEGF and basic FGF transcripts, induction of antioxidant defense genes including SOD2 and metallothionein isoforms, and modulation of the MMP-2 and TIMP-1/2 balance toward non-fibrotic remodeling

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Then, mitochondria were put into state II by adding 5 mM succinate