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We only mice included mice that were of sufficient body weight at the start of the experiment, typically at least 80% of the average littermate weight of the same sex and genotype

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Clinical improvement was also observed in oxidative stress markers, with improvements in methionine levels (p=0.05), homocysteine levels (SAH, p=0.007) and the ratio of S-adenosylmethionine (SAMe) to SAH (p=0.007), indicating improvement with methylation at the cellular level and a decrease in oxidative stress in the body 2

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