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The molecular mechanisms underlying OIPN are complex, with multi-targets and various cells causing neuropathy

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doi: 10.1155/2012/707941

These include host-related factors (e.g., immune response and cytokine profile), immuno-factors, drug pharmacokinetics (e.g., metabolism and adherence to treatment), and parasite-specific factors, such as genetic plasticity and co-infections (Figure 1)

Tirzepatide long-term data extends through the multi-year SURPASS trial extensions and post-marketing surveillance