The bioavailability problem Absorption comparison: Injection: 80-100% bioavailability (nearly all absorbed) Nasal spray: 30-70% bioavailability (varies by peptide) Oral: 0-5% bioavailability (most peptides destroyed) Why nasal lower than injection: Must penetrate nasal mucosa (barrier) Some drips down throat (swallowed = lost) Variable absorption efficiency Technique-dependent Individual variation high What this means: You need MORE peptide via nasal spray Typically 2-3x higher dose than injection Example: 1mg injection = 2-3mg nasal Increases cost significantly But still cheaper/easier than injection for some Conversion guidelines by peptide PT-141: Injection: 1.5-2mg typical dose Nasal equivalent: 3-5mg Conversion ratio: 2-3x Semax: Designed for nasal use (no conversion needed) Standard nasal dose: 200-600mcg per spray 2-3 sprays per nostril typical Follow product guidelines BPC-157 (if attempting nasal): Injection: 250-500mcg Nasal (estimated): 750-1500mcg But: Injection or oral likely better Nasal BPC-157 not well-studied General conversion approach: Start with 2-3x injection dose Assess results after 2-3 uses Increase by 25-50% if weak effects Find minimum effective nasal dose Individual variation significant Cost implications: Using 2-3x more peptide = 2-3x cost Nasal spray more expensive per dose Trade-off: Convenience vs cost Worth it for needle-phobic Not worth it if injections acceptable Use peptide cost calculator to compare routes
Specific activation of the glucocorticoid receptor and modulation of signal transduction pathways in human lens epithelial cells
and, most importantly, protect the skin from poor texture and thereby lead to healthy and soft skin
Cell Rep 10 , 17221734 (2015)
Maiti A, Rausch CR, Cortes JE, Pemmaraju N, Daver NG, Ravandi F, MD, Garcia-Manero G, Borthakur GM, Naqvi K, Ohanian M, Short NJ, Alvarado Y, Benton CB, Kadia TM, Takahashi K, Yilmaz ME, Jain N, Kornblau, SM, Montalban Bravo G, Sasaki K, Andreeff M , Bose P, Ferrajoli A, MD, Issa GC, Jabbour E, Masarova L, Rytting ME, Thompson P, Wang SA, Konoplev S, Chen Z, Goswami M, Maduike R, Guerrero JA, Zhang Q, Cavazos A, Ma H, Bivins C, Wade A, Adewale SL, Tse S, Thomas R, Vaughan K, Pierce SA, Ning J, Qiao W, Welch JS, Kantarjian HM, Konopleva MY, DiNardo CD
