Cell Tissue Res 377 (2), 153159
Dysregulation of adrenal hormones can lead to increased production of ROS, hence contributing to oxidative stress

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The Y296A variant has a considerably slower rate for flavin reduction than observed with the U597C, and the exponential fits to this event could not be extrapolated to the same t zero absorbance value suggesting that a rapid-equilibrium binding event precedes it
This does not mean the molecule is ineffective