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The compound's ability to reverse age-related deficits in fitness, fur density, renal function, and reproductive health in animal models provides researchers with unprecedented opportunities to study the causal relationships between cellular senescence and aging phenotypes

Various structurally related analogs to BN-82451 include LY-178002, LY-256548, ONO-144, and MK-477

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doi: 10.3389/fphar.2021.760331 [DOI] [PMC free article] [PubMed] [Google Scholar] 5.Dalbeth N, Choi HK, Joosten LAB, et al

Langman CB, Greenbaum LA, Grimm P, Sarwal M, Niaudet P, Deschenes G, Cornelissen EA, Morin D, Cochat P, Elenberg E, Hanna C, Gaillard S, Bagger MJ, Rioux P (2014) Quality of life is improved and kidney function preserved in patients with nephropathic cystinosis treated for 2 years with delayed-release cysteamine bitartrate