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From an evolutionary perspective, the activation of the ACTH/HPA axis and sympathetic spinal system, along with the diminished function of the prefrontal cortex, results in a diminished ability to seek and experience pleasure, reduced food intake, decreased sexual activity, and sleep apnea

References Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al

Additionally, many intracellular or latent fungal cells can enter a dormant state, resulting in downregulation of drug targets, reduced membrane permeability, and decreased susceptibility to treatment (Uribe-Querol and Rosales, 2020)

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