What it does not show: efficacy in chronic tendinopathy, in non-rodent species under controlled conditions, in humans, or under sham-injection-controlled and pre-registered protocols
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Versions of this TBM are also found in other telomere-associated proteins that are recruited through similar domain:peptide interactions with TRF1 via the consensus motif F-X-L-X-P-X-(K/R) 3 , such as the telomerase inhibitor Pin2/TRF1-interacting protein (PinX1) 7,16 and the meiosis-specific telomere binder TERB1 17
This interaction prevents actin polymerization and promotes actin sequestration, thereby facilitating cellular migration and morphological changes essential for wound healing and tissue repair
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