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Vitamin B12 monitoring is not routinely indicated for patients on GLP-1/GIP therapy alone but may be considered for those also taking metformin or with risk factors for deficiency

This article explains the trial-based dosing rationale, escalation schedules, influencing factors, side effects, and the current regulatory status in the UK

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When commencing B12 replacement therapy, it is essential to recognise that pre-existing joint conditions will not resolve with vitamin supplementation alone and may require separate rheumatological assessment and management according to NICE guidelines