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Common Causes of "Leaky Gut" Multiple factors can contribute to increased intestinal permeability, and while scientific research continues to explore the full extent of these connections, the following are commonly recognized triggers: Diet especially when its high in processed foods, refined sugars, and artificial additives and preservatives, can disrupt gut microbiota and weaken the intestinal barrier

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Int J Pharmaceutics: X

Additionally, glutathione disulfide (GSSG) is involved in the degradation of drug delivery systems containing disulfide bonds, which allows for targeted drug release in cancer therapy