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Additionally, iron chelators have been shown to improve the prognosis of IS in mammals (Wu et al., 2018)

Given that CoQH2 serves as an alternative anti-ferroptosis system operating in parallel with GPX4, the differential metabolic environments between malignant and normal cells likely contribute to the divergent effects of lactate on ferroptosis sensitivity observed across these cellular contexts

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The integrity of the PR layer is heavily influenced by the retinal pigment epithelium (RPE), which consists of cells with sheet-like microvilli that interact with the outer PR segments extending from the outer retinal surface [172,173]