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While its ability to influence multiple pathways of repair is supported by compelling preclinical data, the absence of high-quality human trials, the FDAs strict regulatory stance, and the risk of contamination from unregulated sources raise serious safety and legal concerns (including malpractice concerns and fines)

[DOI] [PubMed] [Google Scholar] 142.Magnus MC, Karlstad , Hberg SE, et al

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Cleaved Pol was concentrated and loaded onto a MonoS column in TEV cleavage buffer, followed by elution using a linear gradient to 25 mM Tris pH 7.5, 1 M NaCl