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A further 114 were judged ineligible through the detailed abstract review and 52 through the full-text review, with most excluded because they focused on young people not adults (43), because the policy was unclear or not evaluated (31), or because the study examined cessation support but did not assess population reach (27)

A meta-analysis from 2018, conducted on 61 RCT, showed that one year after people quit smoking with the assistance of firstline smoking cessation medications (and some behavioral help), only approximately 20% of them sustained abstinent, as compared to around 12% who did not take medication

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There are several underlying mechanisms explaining the positive association between tobacco smoking and PAD risk