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Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcription factor upregulating the antioxidant response element (ARE)-mediated expression of antioxidant and detoxifying enzymes, and the Nrf2-antioxidant pathway is critical in host defense against acute lung injury (ALI) 24

Strenuous physical activity can induce oxidative stress, a state whereby the production of reactive oxygen species (ROS) exceeds that of the antioxidant defense capacity of the body 6

It may also enhance uric acid excretion by modulating renal transporters

And yet taking melatonin as a supplement is not turned out to be extraordinarily helpful

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