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Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration

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Unlike endocrine peptides, GHK-Cu does not act through a single receptor system

Maquart, Pickart, and colleagues established this in fibroblast culture in 1988 ( FEBS Letters ) and confirmed it in vivo in rat wound models in 1993 ( Journal of Clinical Investigation ) 5 6

At the time, techniques for performing chemical analyses were not well-refined