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Histopathological examination using H&E and AB-PAS staining revealed severe pathological changes in the colonic epithelium of DSS-treated mice

10.3390/ijms20236039 53 ChistiakovD

However, it's important to contextualize this assessment within the limitations of the available evidence: most safety data comes from relatively small studies, often of short-to-moderate duration, conducted primarily in the Soviet Union, Russia, and Eastern Europe where methodological standards and reporting practices have sometimes differed from Western pharmaceutical trial requirements

Poh CM, Carissimo G, Wang B, Amrun SN, Lee CY, Chee RS, et al