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7.3 Innate immune sensing and bidirectional crosstalk Not only does it modulate the T and B lymphocytes, but the innate immunity sensing of gut metabolites by the immune system is also fundamental to bone homeostasis
Inflammation Research, 58(8), 504-512
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In this study, we demonstrate all the tenets of trained immunity modulation as a result of SIRT3 overexpression: (1) there is long-term functional reprogramming of HSCs by SIRT3 expression, as demonstrated by decreased HSC response to trained immunity programs, reduced inflammation and improved function of distant tissues (Figs
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