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Tirzepatide is a first-in-class dual incretin receptor agonist a single molecule that activates both the GIP (glucose-dependent insulinotropic polypeptide) and the GLP-1 (glucagon-like peptide-1) receptors, which is why it is often nicknamed a twincretin. [7] By engaging two incretin pathways it enhances glucose-dependent insulin secretion, promotes satiety, and delays gastric emptying, producing large effects on both glycemic control and bodyweight

Regular exercise is also equally important

MicroRNA-26b-5p alleviates murine collagen-induced arthritis by modulating Th17 cell plasticity

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doi: 10.1038/s41574-021-00615-w 141