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*Correspondence: Kyung-Do Han, [email protected] Wan Kim, [email protected] This article was submitted to Dermatology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Glutamate is the most abundant excitatory transmitter in the central nervous system, utilized at 50- 70% of cortical synapses (1, 2)

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AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation

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