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[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head

These results are in line with previous findings indicating that inhibition of mitochondrial complex I synergizes with mitochondrial antioxidants in impairing cancer cell fitness, supporting the notion that complex I is a dominant determinant of viability ( Figure 2 2.3 DPI synergizes with vincristine and MitoQ in reducing cell viability of MNA NB cells Finding synergistic drug combinations allows for combining drugs at lower concentrations, which is an important strategy for enhancing therapeutic efficacy while minimizing adverse effects

Theranostics 8 (4), 10591074

16Syprine (trientine hydrochloride) Capsules