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Chronic hyperuricemia promotes the deposition of monosodium urate crystals in joints and renal tubules, leading to gout 327 and kidney stones, 328 respectively

These effects are mediated through inhibition of the NF-B/NLRP3/caspase-1 and Bax/Bcl-2/caspase-3 pathways, alongside activation of Nrf2/HO-1, p-AMPK, and -Klotho signaling (Khallaf et al

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Nobiletin (136) upregulates NRF2, enhancing the antioxidant stress capacity in the kidneys of diabetic mice