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FBXW7, an E3 ubiquitin ligase, forms a complex with ASH2L to promote KLF5 ubiquitination and proteasomal degradation, thereby inhibiting NOTCH3 transcription and attenuating vascular smooth muscle cell abnormal proliferation and pulmonary vascular remodeling in PH

Drag , meaning womens clothing worn by a man, first appeared in the mid-19th century, though its origin is uncertain

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There are also resources for parents