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i.p) has been shown to result in an increase in glutamate in the extracellular space by binding to astrocytic CB 1 Rs in mice, contributing to long term depression at synapses and impairments in working memory (Navarrete and Araque, 2010

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The stiffness of the repair tissue also increased to nearly 9 N/mm with TB-500, compared to approximately 6 N/mm in the controls

The average increase has been variously reported from 2 fold to 5 fold, with individual half-lives over 500 hours reported