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Human mutation, 13(5), 362375.[PubMed] [Wiley] Scalise V, Balia C, Cianchetti S, et al

Genetic disorders contributing to BBB dysfunction BBB dysfunction has been reported in several rare inherited human monogenic neurological diseases with genetic mutations affecting individual cell types within the BBB, causing specific defects in BBB development, maintenance and transport

Similarly, in pancreatic ductal adenocarcinoma (PDAC) and NALM-6 leukemia cells, membrane lipid remodeling involving polyunsaturated fatty acidcholesterol esters (PUFA-CEs)generated via the acyl-CoA synthetase long-chain family member 4 (ACSL4)sterol o-acyltransferase 1 (SOAT1) pathway and regulated by solute carrier family 47 member 1 (SLC47A1)drives ferroptotic sensitivity [59]

Copper toxicity: A theoretical concern given the copper content

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