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Tesamorelin has randomised, placebo-controlled trial evidence for visceral fat reduction in HIV patients with lipodystrophy, with one JAMA study reporting a net -42 cm change in VAT versus placebo

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However, the latest REDEFINE-4 results suggest that tirzepatide still holds a modest efficacy advantage in overall weight reduction

Studies with PYY agonists administered intravenously have shown reduction in food intake with increased satiety [92, 93], however, a nasal PYY agonist showed minimal efficacy with poor tolerability [94]

Ajami et al., 2018