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Blood 118 , 13051315 (2011)

Neuron-mediated regulation of CBF Neurons release chemical signals that directly or indirectly influence receptors on pericytes and astrocytes, resulting in either decreased CBF due to depolarization and cell contraction or increased CBF through hyperpolarization and cell relaxation

Genome Res 27(8):1287-1299, 2017

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Distinct development goals In addition, stable long-acting amylin receptor activity Neutral-pH formulation Reduced fibril formation tendency However, large enough to matter in the study weight reduction with favorable side-effect profile For example, potential for combination or combined formulation with other peptide therapies Therefore, Early studies supported continued development