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Slow titration schedules, typically adding one dose increment every four weeks, appear to reduce dropout rates due to gastrointestinal side effects

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These effects relate to tissue growth and fluid changes in connective structures

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5h) were gone in the eyes injected with AAV2-shTMEM19, In addition, erucamide-induced preservation of ONL and INL thicknesses was also lost in TMEM19-knockdown eyes (Extended Data Fig