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A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles

And it explains why sleep becomes harder, shallower, and less restorative as you age, no matter how disciplined your bedtime routine is

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As the concentration of ethanol increases in the liver the -ADH isoform, encoded by the ADH4 gene, contributes significantly to overall hepatic ethanol oxidation