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In the case of deficiency of these enzymes (due to gene polymorphisms, or acquired by events such as viral infections, as in HIV infection), these accumulated arene-oxide intermediates act as haptens, stimulating the immune response or binding to tissue macromolecules and causing direct cell damage

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Silken and bold, this Rococo-style dress in striking red and black captivates the eye with its dramatic design

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It has been in England since 1828, and in the collection of Polesden Lacey in Surrey since 1922