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The separation of human and animal data clarifies translational relevance while emphasizing doseresponse variability across study designs

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As for Japanese patients, approximately half of them showed a history of influenza-like infection within a period of one month preceding DRESS.12 The specific mortality rate for DRESS varies from 3% to 20%, representing a dermatological emergency.1517 Approximately 94% of the patients require hospitalization, with an estimated economic cost to the American healthcare system of at least US$17,000 per patient.16,18 In the study by Wolfson et al