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Patients should avoid self-sourcing it online and speak with a qualified provider before considering any longevity or metabolic compound

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If insufficient compound reaches systemic circulation orally, NNMT inhibition may be incomplete or absent

Human studies using Lactobacillus as a probiotic have often demonstrated decreased body weight and/or body fat in a strain-dependent manner (for a review of human studies, see Crovesy et al., 2017 58 ), suggesting that the NNMTi-and-LD-mediated changes to Lactobacillus relative abundance may be critical to NNMTi-mediated weight loss