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Tryptophan is an essential amino acid obtained solely from the diet and serves as a precursor for serotonin synthesis and it can produce seratonin via tryptophan hydroxylase 1 activity in the intestinal enterochromaffin cells (Jenkins et al., 2016)

These properties make DSIP a useful tool for studying neurochemical responses to stress and the downstream metabolic and endocrine effects of HPA axis activation

[DOI] [PubMed] [Google Scholar] 193.Kean RB, Spitsin SV, Mikheeva T, Scott GS, Hooper DC