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At the same time, cigarette smoke can induce an unbalanced release of lipid mediators that is characterized by a reduced prostacyclin (prostaglandin I2 or PGI2)/thromboxane A2 (TXA2) ratio, which may contribute to pulmonary vascular remodeling [100]

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Other studies did not show any bronchodilator effect [30]

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Consistent with previous studies, we found that urinary cotinine level was negatively associated with TSH level after controlling for age, height, weight, health behaviors (alcohol consumption, and exercise), and urinary iodine level