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[1] The effects were even more pronounced in aged animals

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This study was limited to the subgroup of patients with prediabetes with the primary aim to assess the proportion of individuals who developed T2D 18

Split dosing becomes valuable when single dosing produces inconsistent results, when doses above 400mcg are needed, or when evening administration fits better into lifestyle patterns

Am J Clin Nutr 80:16111617 Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Nataf R, Geier MR (2009) Biomarkers of environmental toxicity and susceptibility in autism