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S2.4 Comparison between HH curves, pHp, and amount of niclosamide in solution To complete this theoretical assessment, plotted in Figure S5 (red symbols) is the pHp curve, giving the maximum amount of niclosamide expected to be in solution (uM) versus the solution pH (right axis) using the values derived from experiment of pKa = 6.87, S o = 1.77uM

However, given FABP5s broad metabolic roles, tissue-restricted or transient inhibition will likely be needed to avoid systemic lipid perturbation

[221], Wu et al

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Step 2: Clean both vial tops Wipe the rubber stopper on both the peptide vial and bacteriostatic water vial with fresh alcohol swabs