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In the body, fat-soluble vitamins are transported like lipids and are crucial components of cell membranes

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Moreover, MEK and CDK4/6 inhibitors have been found to induce senescence in fibroblasts, triggering the secretion of neutrophil-derived (ND) factors that recruit myeloid-derived suppressor cells (MDSCs) into the TME, ultimately suppressing antitumor immunity (Morris et al., 2022)

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observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )