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conducted a 12-week facial study on 67 women and reported that GHK-Cu cream applied twice daily improved aged skin appearance, increased thickness, reduced wrinkles and strongly stimulated dermal keratinocyte proliferation as determined by histological analysis of biopsies

It also suppresses TGF-alpha/Smad 2/3 signaling to reduce fibrotic tissue formation and promote balanced remodeling 3

Menopause 26 (1), 3238

Specifically, Feliciano et al