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Although Th2-associated cytokines, such as IL-4 and IL-13, may promote fibrogenic responses, the overall contribution of Th2 cells to MASH is still inconclusive (127, 128) ( Figure 6A )

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BPC-157 has been observed to downregulate pro-inflammatory cytokines and protect against NSAID-induced tissue damage, while TB-500 may modulate macrophage activity and support immune cell migration