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[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

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Each time a cell divides, its telomeres shorten slightly, a process the National Human Genome Research Institute describes in its explanation of how telomeres protect chromosomes

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