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You need to consider the following factors when discussing dosage with your doctor

High doses may cause temporary headaches due to increased NAD+ turnover and mitochondrial activity

In a 2022 study on vitamin B12 deficiency in overt and subclinical hypothyroidism, researchers found that the rates of vitamin B12 deficiency are higher in patients with hypothyroidism compared to the general population

IV therapy is extremely beneficial for patients experiencing fatigue, chronic illness, brain fog, difficulty losing weight, chronic dehydration, inflammatory conditions, migraines and/or chronic headaches, or patients wanting assistance detoxing

Its an old wives tale, says David Heber, M.D., director of UCLAs Center for Human Nutrition