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doi: 10.1024/0300-9831/a000659

This international uniformity creates a target that is equal, compelling, and easy to communicate

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This gives it a builtin targeting mechanism for gutfocused research and makes oral delivery particularly relevant in colitis models

But they are the direct mechanistic bridge to the more serious cardiovascular signal discussed below: the same sodium-and-water retention that produces mild ankle swelling in a robust 65-year-old can, in a frail patient with limited cardiac reserve, contribute to volume overload and clinical heart failure