Finally, the fermentation was scaled up in a 5-L fermentor, and the highest titer and yield were improved to 5680 mg/L and 45.13 mg/g, respectively, by optimizing the addition conditions of amino acids (40 mM added after 40 h)
In combination with GLP-1 receptor agonists, dual hormonal pathway activation has demonstrated synergistic reductions in body weight and glycemic parameters in preclinical models supporting the investigational framework for combination metabolic therapies
739 Surget A, Tanti A, Leonardo ED, Laugeray A, Rainer Q, Touma C, et al
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Barboza EP, de Souza RO, Caula AL, Neto LG, Caula Fde O, Duarte ME