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While these are different trials with different designs and not a direct head-to-head comparison, the data suggests retatrutide may deliver greater weight loss

Plausible degradation pathways include: Serum aminopeptidases (cleaving from the N-terminus) Endopeptidases (internal bond cleavage) Hepatic uptake and degradation Renal clearance (though direct renal excretion of intact peptide of this size is typically limited) Whether BPC-157 generates active metabolites i.e., smaller peptide fragments that retain biological activity is not established in the public literature

The biological effect thus persists well beyond plasma presence

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Benita S, Levy MY