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Upchurch GR Jr, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr, and Loscalzo J (1997)

The expanded range of metabolic dysfunction in children with persistent frequent seizures is associated with developmental delay, and if surgical treatment is not available, medical treatment to control seizures may improve neurocognitive outcomes (116)

However, in clinical trials targeting severe cognitive impairment, chronic fatigue syndrome, or neuropathy, therapeutic doses usually range from 1,500 mg to 3,000 mg (1.5g 3g) daily

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Moreover, PGC-1 activator ZLN005 mitigates renal injury by accelerating mitochondrial clearance in mice with cisplatin-induced AKI, increasing co-localization between LC3 and damaged mitochondria [51]