J Neurochem 73:14221430 Had-Aissouni L (2011) Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance
In one animal study, who were given 2 grams of ALCAR daily for 50 days, ALCAR boosted blood levels of ALCAR by 43%.[i] ALCAR does everything that L-Carnitine does, but by adding an acetyl group , it but can also cross the blood-brain barrier
HA, SY and MM participated in the design of the study, performed animal experiment and statistical analysis
observed in human keratinocytes that IR-induced GSH depletion occurred despite unchanged expression of SLC7A11 and apparent upregulation of Glutamate-Cysteine Ligase, the rate-limiting enzyme responsible for GSH synthesis, suggesting the role of another GSH regulator [38]
Finally, introduction of a Cys-to-Ser mutation at position 455 in TRAF3, which aligned with Cys390 of TRAF6, led to reduced induction of IFN- by HSV-2 after transfection into traf3-/- MEFs, and importantly abolishment of the sensitivity towards LNAC treatment, which was found in traf3-/- cells transfected with WT TRAF3 (Figure 5G)
