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Similarly, trametinib (a MEK inhibitor) enhances the transcription of ferritin heavy chain (FTH1) and ferritin light chain (FTL) and promotes ferritinophagy through NCOA4 while reducing ferroportin expression, thereby increasing intracellular iron levels and ultimately triggering ferroptosis in PDAC cells [22]

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Clin Microbiol Rev 12(4):501517 Podust LM, Poulos TL, Waterman MR (2001) Crystal structure of cytochrome P450 14-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

A random-effects network meta-analysis with a Bayesian framework was performed to calculate the mean difference (MD) and 95 % credible intervals (CrIs)