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The Major Antihistamine Effects of Diphenhydramine Prevents Histamine-Mediated: constriction of respiratory smooth muscle rapid vasodilation in blood vessels increased capillary permeability and subsequent edema sensations of itching, pain, and flare formation increase in heart rate and strength of contraction DPH a First-Generation Antihistamine The distinction of the first-generation antihistamine is given to various antihistamines

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For decades, the NHLBI has advanced discovery science that has transformed health outcomes by tackling some of the most pressing public health issues

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